SrasV1, Main, Exploration, bibRecord, 001273

ORF8-Related Genetic Evidence for Chinese Horseshoe Bats as the Source of Human Severe Acute Respiratory Syndrome Coronavirus

Identifieur interne : 001273 ( Main/Exploration ); précédent : 001272; suivant : 001274

ORF8-Related Genetic Evidence for Chinese Horseshoe Bats as the Source of Human Severe Acute Respiratory Syndrome Coronavirus

Auteurs : Zhiqiang Wu ; Li Yang ; Xianwen Ren ; Junpeng Zhang ; Fan Yang ; Shuyi Zhang [République populaire de Chine] ; Qi Jin

Source :

The Journal of Infectious Diseases [ 0022-1899 ] ; 2015.

RBID : PMC:7107392

Descripteurs français

KwdFr :
- ARN viral (génétique), Analyse de regroupements, Analyse de séquence d'ADN, Animaux, Chine, Chiroptera (virologie), Données de séquences moléculaires, Génotype, Humains, Protéines de la matrice virale (génétique), Similitude de séquences, Virus du SRAS (), Virus du SRAS (génétique), Évolution moléculaire.
MESH :
- génétique : ARN viral, Protéines de la matrice virale, Virus du SRAS.
- virologie : Chiroptera.
- Analyse de regroupements, Analyse de séquence d'ADN, Animaux, Chine, Données de séquences moléculaires, Génotype, Humains, Similitude de séquences, Virus du SRAS, Évolution moléculaire.
Wicri :
- geographic : République populaire de Chine.

English descriptors

KwdEn :
- Animals, China, Chiroptera (virology), Cluster Analysis, Evolution, Molecular, Genotype, Humans, Molecular Sequence Data, RNA, Viral (genetics), SARS Virus (classification), SARS Virus (genetics), Sequence Analysis, DNA, Sequence Homology, Viral Matrix Proteins (genetics).
MESH :
- chemical , genetics : RNA, Viral, Viral Matrix Proteins.
- geographic : China.
- classification : SARS Virus.
- genetics : SARS Virus.
- virology : Chiroptera.
- Animals, Cluster Analysis, Evolution, Molecular, Genotype, Humans, Molecular Sequence Data, Sequence Analysis, DNA, Sequence Homology.

Abstract

Several lineage B betacoronaviruses termed severe acute respiratory syndrome (SARS)–like CoVs (SL-CoVs) were identified from Rhinolophus bats in China. These viruses are characterized by a set of unique accessory open reading frames (ORFs) that are located between the M and N genes. Among unique accessory ORFs, ORF8 is most hypervariable. In this study, the ORF8s of all SL-CoVs were classified into 3 types, and, for the first time, it was found that very few SL-CoVs from Rhinolophus sinicus have ORF8s that are identical to that of human SARS-CoV. This finding provides new genetic evidence for Chinese horseshoe bats as the source of human SARS-CoV.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7107392

DOI: 10.1093/infdis/jiv476
PubMed: 26433221
PubMed Central: 7107392

Affiliations:

République populaire de Chine

Le document en format XML

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<term>China</term>
<term>Chiroptera (virology)</term>
<term>Cluster Analysis</term>
<term>Evolution, Molecular</term>
<term>Genotype</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>RNA, Viral (genetics)</term>
<term>SARS Virus (classification)</term>
<term>SARS Virus (genetics)</term>
<term>Sequence Analysis, DNA</term>
<term>Sequence Homology</term>
<term>Viral Matrix Proteins (genetics)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (génétique)</term>
<term>Analyse de regroupements</term>
<term>Analyse de séquence d'ADN</term>
<term>Animaux</term>
<term>Chine</term>
<term>Chiroptera (virologie)</term>
<term>Données de séquences moléculaires</term>
<term>Génotype</term>
<term>Humains</term>
<term>Protéines de la matrice virale (génétique)</term>
<term>Similitude de séquences</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (génétique)</term>
<term>Évolution moléculaire</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Viral</term>
<term>Viral Matrix Proteins</term>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>Several lineage B betacoronaviruses termed severe acute respiratory syndrome (SARS)–like CoVs (SL-CoVs) were identified from <italic>Rhinolophus</italic>
 bats in China. These viruses are characterized by a set of unique accessory open reading frames (ORFs) that are located between the M and N genes. Among unique accessory ORFs, ORF8 is most hypervariable. In this study, the ORF8s of all SL-CoVs were classified into 3 types, and, for the first time, it was found that very few SL-CoVs from <italic>Rhinolophus sinicus</italic>
 have ORF8s that are identical to that of human SARS-CoV. This finding provides new genetic evidence for Chinese horseshoe bats as the source of human SARS-CoV.</p>
</div>
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ORF8-Related Genetic Evidence for Chinese Horseshoe Bats as the Source of Human Severe Acute Respiratory Syndrome Coronavirus

ORF8-Related Genetic Evidence for Chinese Horseshoe Bats as the Source of Human Severe Acute Respiratory Syndrome Coronavirus

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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